NextGENeLR delivers enhanced precision, streamlined workflows, and powerful reporting tools to address critical challenges in long-read sequencing analysis.
Designed for PacBio® and Oxford Nanopore® data, NextGENeLR now makes complex variant detection and interpretation accessible to all researchers—without compromising accuracy.
Key New Features in NextGENeLR
1. Breakthroughs in Precision
NextGENeLR delivers major advancements in variant detection accuracy and interpretive power—designed specifically for the demands of long-read sequencing. From single-nucleotide changes to complex genomic rearrangements, these innovations redefine precision in genomic analysis.
Whether you're investigating inherited disorders, infectious diseases, or structural variations, these new tools provide the clarity and reliability needed for confident discovery.
Key Enhancements in Variant Detection:
- Improved Variant Calling
- Comprehensive Structural Variation Detection
- Advanced Haplotyping
- Mitochondrial Genome Analysis
- Accurate STR Expansion Profiling
Improved Variant Calling
NextGENeLR’s updated algorithms now identify and filter common noise patterns, significantly improving the accuracy of SNV and short indel detection.
Comprehensive Structural Variation Detection
Overcome the limitations of short-read technologies with reliable detection of large insertions, deletions and translocations—all from a single analysis pipeline.
Advanced Haplotyping
Resolve phasing challenges with dedicated Haplotype Reports for viral (e.g.,COVID-19) and human (e.g., HBB gene) sequences, plus Pedigree Reports for familial studies.
Mitochondrial Genome Analysis
Sequence the entire mitochondrial genome in just 2 amplicons, enabling high-resolution analyses for haplotyping and disease research.
Accurate STR Expansion Profiling
Precisely measure long repetitive sequences (e.g., those linked to Huntington’s disease and Fragile X syndrome) with long-read-specific tools.
2. Accessible to All Researchers
NextGENeLR puts powerful long-read analysis directly in the hands of biologists and clinicians through its intuitive graphical interface.
Designed specifically for domain experts, it eliminates coding barriers with guided, one-click workflows—seamlessly integrating every step from raw data processing to final report generation in a single, user-friendly environment.
3. Effortless Workflows
NextGENeLR requires no bioinformatics expertise—its intuitive interface combines analysis, visualization, and reporting in one unified workspace, eliminating complex scripting. Researchers can effortlessly run a batch of new samples while simultaneously reviewing the results of a previous project in the viewer.
4. Publication-Ready Results
NextGENeLR is capable of delivering publication-ready results with high-resolution visualizations of BAM alignments, haplotyping results and STR expansion profiles. The platform also provides a variety of output options, generating both standardized analysis files (BAM, annotated VCF) and textual outputs for seamless sharing and collaboration.
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