--- title: Guides for Sequencing, Fragment and Forensics | SoftGenetics Team description: Explore SoftGenetics' resources for genetic data analysis, including software guides, webinars, and tutorials to enhance your research with precision and efficiency. image: https://go.softgenetics.com/hubfs/SoftGenetics%20Guides.jpg --- Explore the Scientific R&D Platform ![Top Bar background texture](https://flow-cytometry.net/wp-content/uploads/2024/07/nav-bg.png) ![](https://flow-cytometry.net/wp-content/uploads/2024/07/Luma-TM.png) Scientific intelligence platform for AI-powered data management and workflow automation [Explore Luma  ](https://www.dotmatics.com/luma-data-management-platform) [![Prism logo](https://flow-cytometry.net/wp-content/uploads/2024/07/Prism-Logo-White-2.png) Statistical analysis and graphing software for scientists](https://www.graphpad.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar) [![Geneious logo](https://flow-cytometry.net/wp-content/uploads/2024/07/Geneious-Logo-White-2.png) Bioinformatics, cloning, and antibody discovery software](https://www.geneious.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar) [![SnapGene logo](https://cdn.labarchives.com/assets/16.23.0/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-SnapGene.svg) Plan, visualize, & document core molecular biology procedures](https://www.snapgene.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar) [![Protein Metrics logo](https://cdn.labarchives.com/assets/16.23.0/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-Protein-Metrics.svg) Proteomics software for analysis of mass spec data](https://proteinmetrics.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar) [![LabArchives logo](https://flow-cytometry.net/wp-content/uploads/2024/07/LabArchives-Logo-White-2.png) Electronic Lab Notebook to organize, search and share data](https://www.labarchives.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar) [![OMIQ logo](https://cdn.labarchives.com/assets/16.23.0/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-OMIQ.svg) Modern cytometry analysis platform](https://www.omiq.ai/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar) [![FCS Express logo](https://cdn.labarchives.com/assets/16.23.0/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-FCS-Express.svg) Analysis, statistics, graphing and reporting of flow cytometry data](https://denovosoftware.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar) [![Easy Panel logo](https://flow-cytometry.net/wp-content/uploads/2024/07/EasyPanel-Logo-White-2.png) Intelligent panel design & inventory management for flow cytometry](https://flow-cytometry.net/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar) [![nQuery logo](https://cdn.labarchives.com/assets/16.23.0/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-nQuery.svg) Software to optimize designs of clinical trials](https://www.statsols.com/) [![M-Star logo](https://flow-cytometry.net/wp-content/uploads/2024/07/M-Star-Logo-White-2.png) Computational fluid dynamics (CFD) software for engineers and researchers](https://www.mstarcfd.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar) [![SoftGenetics logo](https://flow-cytometry.net/wp-content/uploads/2024/07/SoftGenetics-Logo-White-2.png) Genetic analysis software for research, forensics & healthcare applications](https://softgenetics.com/?utm_medium=referral&utm_source=nquery&utm_campaign=dotmatics-top-bar) [Explore the Scientific Software  ](https://www.dotmatics.com/portfolio) [![SoftGenetics-Logo-Dark](https://go.softgenetics.com/hubfs/SoftGenetics-Logo-Dark.svg "SoftGenetics-Logo-Dark")](https://softgenetics.com/) - Products Sequencing [Mutation Surveyor](https://www.softgenetics.com/products/mutation-surveyor/) [NextGENe](https://www.softgenetics.com/products/nextgene/) [NextGENeLR](https://www.softgenetics.com/products/nextgenelr/) [Geneticist Assistant](https://www.softgenetics.com/products/geneticist-assistant/) Fragment [GeneMarker](https://www.softgenetics.com/products/genemarker/) [ChimeRMarker](https://www.softgenetics.com/products/chimermarker/) Forensic [GeneMarkerHID](https://www.softgenetics.com/products/genemarkerhid/) [GeneMarkerHTS](https://www.softgenetics.com/products/genemarkerhts/) [MaSTR](https://www.softgenetics.com/products/mastr/) [NOCIt](https://www.softgenetics.com/products/nocit/) - Resources Recommended [How To Guides](https://go.softgenetics.com/guides) [User Manual](https://www.softgenetics.com/information/downloads/) - [Support](https://support.softgenetics.com/hc/en-us) [Pricing](https://www.softgenetics.com/products/pricing/sequencing/) [Free Trial](https://go.softgenetics.com/information/request-trial/) # SoftGenetics Resources Discover the latest insights and perspectives to lead your research and development ![SoftGenetics Product Webinars](https://go.softgenetics.com/hs-fs/hubfs/Images/Page%20Images/SoftGenetics%20Blog%201.png?width=1280&height=720&name=SoftGenetics%20Blog%201.png "SoftGenetics Product Webinars") [Product Webinars](https://softgenetics.com/services/analysis-corner-webinars/webinars/) ![SoftGenetics User Guide](https://go.softgenetics.com/hubfs/Images/Page%20Images/SoftGenetics%20Blog%202.png "SoftGenetics User Guide") [Download User Guides](https://softgenetics.com/information/downloads/) ![SoftGenetics Citations & Papers](https://go.softgenetics.com/hubfs/Images/Page%20Images/SoftGenetics%20Blog%203.png "SoftGenetics Citations & Papers") [Citations & Papers](https://softgenetics.com/services/citations-and-papers/) Latest Articles ## Guides on how to confidently analyze your genetic data   [![Probabilistic Genotyping Comes to Wildlife Forensics](https://go.softgenetics.com/hubfs/Probabilistic%20Genotyping%20Comes%20to%20Wildlife%20Forensics.png) Probabilistic Genotyping Comes to Wildlife Forensics Discover how MaSTR™ is revolutionizing wildlife forensics by enabling accurate analysis of mixed canine DNA profiles, overcoming challenges in the field. Read More](https://go.softgenetics.com/guides/probabilistic-genotyping-comes-to-wildlife-forensics) [![What does fragment analysis look like today?](https://go.softgenetics.com/hubfs/March%20Webinar%20-%20Forensic%20CE%20STR%20Analysis%20in%202026%20-%20Playback.png) Solving Forensic DNA Analysis Challenges with GeneMarker®HID Discover how GeneMarkerHID enhances forensic CE STR analysis, addressing workflow challenges with innovative tools for improved accuracy and efficiency. Read More](https://go.softgenetics.com/guides/solving-forensic-dna-analysis-challenges) [![A Hybrid Framework for Autosomal and Y-STR Allele Identification](https://go.softgenetics.com/hubfs/SoftGenetics%20Webinar%20%20-%20A%20Hybrid%20Framework%20for%20Autosomal%20and%20Y-STR%20Allele%20Identification.png) A Hybrid Framework for Autosomal and Y-STR Allele Identification Learn about a hybrid alignment for STR allele identification using GeneMarker®HTS, with high concordance with CE allele calls for forensic applications. Read More](https://go.softgenetics.com/guides/a-hybrid-framework-for-autosomal-and-y-str-allele-identification) [![What does fragment analysis look like today? \[Video\]](https://go.softgenetics.com/hubfs/November%20Webinar%20-%20Fragment%20Analysis%20in%202025%20-%20Playback-2.png) What does fragment analysis look like today? Discover how GeneMarker® and ChimeRMarker® are revolutionizing fragment analysis in 2025 with automated data interpretation and streamlined workflows. Read More](https://go.softgenetics.com/guides/what-does-fragment-analysis-look-like-today) [![Size Calibration FAQs](https://go.softgenetics.com/hubfs/Size%20Calibration%20FAQ.jpg) Size Calibration FAQs Learn the essentials of size calibration in fragment analysis software with practical tips and real-world examples in this informative session Read More](https://go.softgenetics.com/guides/size-calibration-faqs) [![What Is Variant Calling?](https://go.softgenetics.com/hubfs/What%20Is%20Variant%20Calling.jpg) NextGENeLR What Is Variant Calling? Learn the fundamentals of variant calling, key workflows, and tools to confidently identify genetic differences in sequencing analysis with SoftGenetics. Read More](https://go.softgenetics.com/guides/what-is-variant-calling) [![Types of DNA Sequencing: When Should You Use Each?](https://go.softgenetics.com/hubfs/What%20Are%20the%20Main%20Types%20of%20DNA%20Sequencing%20and%20When%20Should%20You%20Use%20Each_.jpg) NextGENeLR Types of DNA Sequencing: When Should You Use Each? Discover the relevance of fragment analysis in genetic research, its applications, and how SoftGenetics software enhances variant detection & analysis. Read More](https://go.softgenetics.com/guides/types-of-dna-sequencing) [![What Is Fragment Analysis and Why Is It Still Essential?](https://go.softgenetics.com/hubfs/What%20Is%20Fragment%20Analysis_.jpg) GeneMarker What Is Fragment Analysis and Why Is It Still Essential? Discover the relevance of fragment analysis in genetic research, its applications, and how SoftGenetics software enhances variant detection & analysis. Read More](https://go.softgenetics.com/guides/what-is-fragment-analysis) [![STR Analysis vs. SNP Genotyping: When to Use Each](https://go.softgenetics.com/hubfs/STR%20Analysis%20vs.%20SNP%20Genotyping.jpg) GeneMarker STR Analysis vs. SNP Genotyping: When to Use Each Compare STR analysis and SNP genotyping to determine the best approach for your research goals. Learn about their unique advantages and hybrid approaches. Read More](https://go.softgenetics.com/guides/str-analysis-versus-snp-genotyping) [![How to Analyze Microsatellites Using Capillary Electrophoresis](https://go.softgenetics.com/hubfs/Analyze%20Microsatellites%20Using%20Capillary%20Electrophoresis.jpg) How to Analyze Microsatellites Using Capillary Electrophoresis Analyze microsatellites using capillary electrophoresis for accurate, high-resolution genetic data in breeding, biodiversity, and conservation studies. Read More](https://go.softgenetics.com/guides/how-to-analyze-microsatellites-using-capillary-electrophoresis) [![Accurate Variant Detection from Long-Read Sequencing](https://go.softgenetics.com/hubfs/July%20Webinar%20-%20Accurate%20Variant%20Detection%20from%20Long-Read%20Sequencing.png) Accurate Variant Detection from Long-Read Sequencing Discover how NextGENeLR enhances long-read sequencing analysis, tackling higher error rates and complex variants for accurate genetic insights Read More](https://go.softgenetics.com/guides/accurate-variant-detection-from-long-read-sequencing) [![What’s New in NextGENeLR?](https://go.softgenetics.com/hubfs/Whats%20New%20in%20NextGENeLR.png) What’s New in NextGENeLR? Discover NextGENeLR: Enhanced precision, effortless workflows, and accessible long-read sequencing analysis for all researchers. Start your free trial. Read More](https://go.softgenetics.com/guides/whats-new-in-nextgenelr) [![Variant Detection Analysis Software Guide](https://go.softgenetics.com/hubfs/SoftGenetics%20Variant%20Detection%20Analysis%20Software.png) Variant Detection Analysis Software Guide Discover how SoftGenetics' variant detection analysis software excels across Sanger, NGS, and long-read sequencing, ensuring accuracy and efficiency in genetic research. Read More](https://go.softgenetics.com/guides/variant-detection-analysis-software-what-why-and-how) [![How Does Probabilistic Genotyping Improve DNA Analysis?](https://go.softgenetics.com/hubfs/SoftGenetics%20Webinar%20%20-%20Probabilistic%20Genotyping.png) How Does Probabilistic Genotyping Improve DNA Analysis? Part 3 of Forensic DNA Analysis Series. Learn how advanced statistical methods and system parameter calibration enhance the accuracy of DNA mixture analysis in forensic science. Read More](https://go.softgenetics.com/guides/probabilistic-genotyping) [![Methods to Evaluate Number of Contributors in DNA Mixtures](https://go.softgenetics.com/hubfs/SoftGenetics%20Webinar%20%20-%20Determining%20Number%20of%20Contributors.png) Methods to Evaluate Number of Contributors in DNA Mixtures Part 2 of Forensic DNA Analysis Series. Explore how the number of contributors in forensic DNA mixtures, enhances accuracy & efficiency - Discover the benefits of NOCIt in DNA analysis. Read More](https://go.softgenetics.com/guides/determining-number-of-contributors-in-dna-mixtures) [![How to Optimize Forensic Genotyping Settings for Accurate DNA Analysis](https://go.softgenetics.com/hubfs/How%20to%20Optimize%20Forensic%20Genotyping%20Settings%20for%20Accurate%20DNA%20Analysis.png) How to Optimize Forensic Genotyping Settings for Accurate DNA Analysis Part 1 of Forensic DNA Analysis Series. Learn key steps for establishing genotyping settings in forensic DNA analysis, from thresholds to audit trails for reliable results. Read More](https://go.softgenetics.com/guides/establishing-forensic-genotyping-settings) [![Mutation Surveyor Video Tutorials](https://go.softgenetics.com/hubfs/Images/Page%20Images/Mutation%20Surveyor%20-%E2%80%A8Video%20Tutorials.jpg.jpeg-1) Mutation Surveyor Video Tutorials Master DNA sequencing analysis with Mutation Surveyor, featuring high accuracy, custom reporting, and robust tools for variant detection. Free 35-day trial today. Read More](https://go.softgenetics.com/guides/mutation-surveyor-video-tutorials) [![Free Webinars for Genetic Data Analysis](https://go.softgenetics.com/hubfs/Webinar.png) Free Webinars for Genetic Data Analysis Free Webinars for Genetic Data Analysis Read More](https://go.softgenetics.com/guides/free-webinars-for-genetic-data-analysis) [![Quick Start Guide](https://go.softgenetics.com/hubfs/Webinar%20(1).png) Quick Start Guide Resources To Help Confidently Analyze Your Genetic Data Read More](https://go.softgenetics.com/guides/quick-start) Load More   Further resources covering Sequencing, Fragment and Forensics [![SoftGenetics-Logo (1)-1](https://go.softgenetics.com/hs-fs/hubfs/SoftGenetics-Logo%20(1)-1.png?width=646&height=135&name=SoftGenetics-Logo%20(1)-1.png "SoftGenetics-Logo (1)-1")](https://www.statsols.com/) 100 Oakwood Avenue, Suite 350 State College, PA 16803, USA [info@softgenetics.com](mailto:info@softgenetics.com) Products - [Mutation Surveyor](https://www.softgenetics.com/products/mutation-surveyor/) - [NextGENe](https://www.softgenetics.com/products/nextgene/) - [Geneticist Assistant](https://www.softgenetics.com/products/geneticist-assistant/) - [NextGENeLR](https://www.softgenetics.com/products/nextgenelr/) - [ChimeRMarker](https://www.softgenetics.com/products/chimermarker/) - [MaSTR](https://www.softgenetics.com/products/mastr/) - [GeneMarker](https://www.softgenetics.com/products/genemarker/) - [GeneMarkerHID](https://www.softgenetics.com/products/genemarkerhid/) - [GeneMarkerHTS](https://www.softgenetics.com/products/genemarkerhts/) - [NOCIt](https://www.softgenetics.com/products/nocit/) Information - [Products](https://www.softgenetics.com/information/products/) - [Downloads](https://www.softgenetics.com/information/downloads/) - [Application Notes](https://www.softgenetics.com/information/application-notes/) - [Free Trial](https://go.softgenetics.com/information/request-trial/) - [Request Quote](https://www.softgenetics.com/information/request-quote/) - [Ordering](https://www.softgenetics.com/information/ordering/) Resources - [Webinars](https://www.softgenetics.com/services/analysis-corner-webinars/webinars/) - [News](https://www.softgenetics.com/services/news/) - [Conferences](https://www.softgenetics.com/conferences/) - [Citations & Papers](https://www.softgenetics.com/services/citations-and-papers/) - [Patents](https://www.softgenetics.com/services/citations-and-papers/#patents) Support - [Contact Us](https://go.softgenetics.com/contact-us) - [Knowledge Base](https://support.softgenetics.com/) - [Support Form](https://www.softgenetics.com/services/support/) ©SoftGenetics, LLC. 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